Here’s the guide I used: https://www.standingpad.org/posts/2024/06/affinity-on-linux/

The only thing I did differently was I used this yaml to make the container: https://gist.github.com/gnat/8b69cf49b68e2349afe5e8cb5af49bf8

There’s a bit of tinkering afterwards, but it runs.

Pretty stable from my testing, outside of a few crashes when I was asking too much of it.

That said Inkscape/gimp/kirta are good alternatives if you are in the market.

While it’s a pain to setup, Affinity does work in Bottles and a specific build of Wine. Not easy to do, but it’s possible.