To evaluate the impact of psilocybin on longevity in vivo, aged (19 month) female mice were treated with vehicle [vehicle is what the psilocybin was suspended in for injection] or psilocybin [actually vehicle + psilocybin] once/month for 10 months; mice were initially given a low-dose (5 mg/kg) for the first treatment followed monthly high-dose (15 mg/kg) treatment for a total of 10 treatments. We elected to utilize 19-month old mice, which is roughly equivalent to 60–65 human years, in order to evaluate its therapeutic potential as a clinically-relevant anti-aging intervention.

Within 30 min post-treatment, mice exhibited increased head-twitch response, which is a well-established behavioral indicator of hallucinogenic impacts of psilocybin in mice. Both psilocybin and vehicle groups exhibited some loss in body weight from the start to end of the treatment protocol, however weight loss was not significantly different in vehicle vs. psilocybin-treated mice. Notably, psilocybin treated mice demonstrated significantly higher survival (80%), compared to vehicle (50%).

Although not quantitatively measured, psilocybin-treated mice exhibited phenotypic improvements in overall fur quality, including hair growth and reductions in white hair compared to vehicle-treated mice.

In summary, we provide the first experimental evidence demonstrating that psilocybin treatment can enhance survival in aged mice.

So, caveats:

• This is the first study; while further studies may show a similar result, we won’t know for sure until they are completed. This could be a fluke. This was neither a double blind nor a placebo study; it is possible things like researcher impacts could influence the outcomes.
• This was neither a double blind nor a placebo study; it is possible things like researcher impacts could influence the outcomes.
• Typical doses for psilocybin are 0.2–0.4 mg/kg in therapeutic settings, 4mg/kg for microdosing, to up to 20 mg/kg to be legitimately tripping; like the mice, if you use this regimen you will need to set aside a day to be tripping once a month, and after 10 months take a heroic dose and have a really big trip. Not impossible to arrange for many people, but this is not a regimen you can do while completely going about your regular day-to-day.

TLDR: Promising results in an under studies area. More studies are required to confirm results. Following this regimen will cause a non-trivial disruption in your monthly routine.

the internet was for porn

Why you think the net was born?

Not the mandatory volunteering to help plan, execute, and clean up after the optional mandatory after-work in-office no-alcohol team building event?

wizard math

the Julius Caesar of our time—Donald Trump

Biiiiig doubt right off the bat, but I’ll keep reading.

We can’t stop people free-riding, it’s part of our nature, the incurable syndrome… Free riders are among us … if we accept that we all have this ancient flaw… we can design policies around that and change our societies for the better.

Right, ok, I guess that makes sense. How do we fix it then?

Self-knowledge: …appearing trustworthy but being selfish can be more beneficial to the individual. We need to recognise that and make a moral choice about whether we try to use people or to work with them.

Ok, sure, for the less-selfish folks who have the capacity for self-awareness. But the more selfish folks already know this because they are exploiting it.

Education: We must teach people to think ethically for themselves, and to give them the tools to do so.

Hmm, big doubt. We’ve been trying to do this for ages in many societies. Not only has it not been a panacea, the selfish often hijack the education systems themselves.

Policy: Goodman believes that exposing free-riders is more beneficial than punishment… suggesting that journalistic work exposing exploitation can be as effective… as criminal punishment.

Ok, you lost me. Maybe the book is better, but this is garbage. I don’t care about changing behaviour, I want to stop the bleeding. Criminal punishment for the criminally sociopathic! This guy and Susan Collins can keep eachother company…

This picture: brought to you by some bullshit AI

No more Miracles on the Hudson, only Meltdowns.

“All the enemies of the Constitution borrow the name and language of patriotism to spread error, discord and false principles… It is thus that public opinion is excited and becomes disorganized; the general will becomes powerless and invalid and patriotism… sometimes seconds, through blind impetuosity, the evil projects of the enemies of our freedom.” -MR

Can’t steal what’s already stolen.

I support this party. And I will buy the hat. Can it be blue with yellow lettering?

Damn right, it’s better than yours

I can teach you, but I’ll have to charge